¿La senescencia celular promueve el envejecimiento biológico? Scoping review

Irviana Molina, Eduvigis Solórzano N.

Resumen


La senescencia celular es un mecanismo de respuesta frente a elementos nocivos, consiste en la detención de las divisiones celulares; por lo cual la célula permanece viable y el daño sufrido no es transmisible a las siguientes generaciones; sin embargo, la evidencia actual indica que este tipo de células son más predominantes en tejidos de individuos con mayor edad biológica y la presencia de ciertos marcadores que expresan daño molecular plantea como objetivo contestar la siguiente pregunta de investigación: ¿la senescencia celular promueve el envejecimiento biológico? Se llevó a cabo una revisión de alcance “Scoping review” con base a la guía de extensión de la declaración PRISMA y con las pautas del Instituto Joanna Briggs para la realización revisiones sistemáticas de alcance, empleando las bases de datos PubMed, Scopus y Google Scholar, se seleccionaron los artículos publicados en los últimos 5 años, En los criterios de inclusión, se aceptaron todos los tipos de estudios posibles publicados en el idioma inglés con fechas entre el 30 noviembre de 2019 hasta el 01 de enero de 2021, la búsqueda arrojó 579 artículos, que luego de su respectiva revisión fueron seleccionados 52. De estos artículos seleccionados (42) se identificaron como estudios documentales de los cuales (40) eran artículos de revisión y (2) emplearon bases de datos provenientes de estudios previos; (11) eran estudios experimentales de los cuales (5) eran estudios in vivo y (6) in vitro. Debido a los múltiples factores celulares y bioquímicos involucrados, se requiere de más datos para inferir una asociación directa de causalidad del envejecimiento sobre los tejidos.

Recibido: 16/02/2021
Aprobado: 25/03/2021


Palabras clave


Senescencia Celular; Biomarcadores; Envejecimiento celular; Inmunosenescencia

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Referencias


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