Sesquiterpenos halogenados en algas del género Laurencia: diversidad, biosíntesis y aplicaciones terapéuticas

Carolina avancesenquimica@ula.ve Serrano-Salas, Sara García-Davis, Ramón Rodríguez-Garza, Vianey González-Villasana, Ezequiel Viveros-Valdez

Resumen


Los sesquiterpenos constituyen una clase diversa de terpenoides de 15 átomos de carbono con relevancia biológica y farmacoló-gica. El objetivo de esta revisión es analizar de manera crítica la clasificación estructural, las rutas biosintéticas y los mecanismos celulares de acción de sesquiterpenos halogenados aislados de algas rojas del género Laurencia. Se integran evidencias experi-mentales que describen la inducción de apoptosis dependiente de p53, la inhibición de angiogénesis mediada por VEGF, la supresión de migración e invasión celular asociada a MMPs e IL-8, así como la alteración del metabolismo energético y el estrés oxidante. En particular, compuestos como el laurinterol muestran perfiles bioactivos consistentes, aunque dependientes del mo-delo experimental. En conjunto, estos hallazgos posicionan a los sesquiterpenos de Laurencia como candidatos relevantes para el desarrollo de estrategias terapéuticas basadas en productos naturales marinos, destacando la necesidad de estudios preclínicos que validen sus mecanismos de acción y seguridad.

Recibido: 01/09/2025
Aceptado: 29/12/2025


Palabras clave


Laurencia; laurinterol; sesquiterpenos; mecanismos celulares; productos naturales marinos

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Referencias


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Depósito Legal: PPI200602ME2232
ISSN: 1856-5301

DOI: https://doi.org/10.53766/AVANQUIM

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