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| Dublin Core |
Elementos de metadatos PKP |
Metadatos para el documento |
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| 1. |
Título |
Título del documento |
Inflammatory mediators in patients with Dengue infection: role in early endothelial damage |
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| 2. |
Creador/a |
Nombre de autor/a, institución, país |
Silvana Vielma; Universidad de Los Andes (ULA); Venezuela, República Bolivariana de |
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| 3. |
Materia |
Disciplina(s) |
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| 3. |
Materia |
Palabra/s clave |
Pro-inflammatory cytokines; Endothelial damage; sICAM-1; sVCAM-1; sIL-2Rα; sTNF-RII/p75; Dengue without warning signs (DwoWS); Dengue with warning signs (DwWS); Severe dengue (SD) |
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| 4. |
Descripción |
Resumen |
Several mechanisms have been proposed to explain the pathogenesis of dengue virus (DENV) infection. One of the most important finding is the production of pro-inflammatory cytokines as responsible of endothelial cells activation, plasma leakage and subsequently, disease severity. Methods: Our aim was to determined levels of inflammatory mediators (IL-8, TNF-α), soluble cell adhesion molecules (sICAM-1 and sVCAM-1) and soluble lymphocyte activation markers (sIL-2Rα, sTNF-RII/p75) during the course of DENV infection. Serum samples from fifty-two patients with confirmed DENV infection were collected during the acute (0-3 days after fever onset) and critical/recovery (4-7 days after onset) phases of the diseases. As controls, sera from non-febrile individuals were included. Patients were classified as dengue without warning signs (DwoWS), dengue with warning signs (DwWS) and severe dengue (SD). |
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| 5. |
Editorial |
Institución organizadora, ubicación |
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| 6. |
Colaborador/a |
Patrocinador(es) |
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| 7. |
Fecha |
(DD-MM-AAAA) |
2014-01-10
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| 8. |
Tipo |
Estado y género |
Artículo revisado por pares |
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| 8. |
Tipo |
Tipo |
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| 9. |
Formato |
Formato de archivo |
PDF |
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| 10. |
Identificador |
Identificador uniforme de recursos |
http://erevistas.saber.ula.ve/index.php/biomedicina/article/view/4605 |
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| 11. |
Fuente |
Título; vol., núm. (año) |
Avances en Biomedicina; 2013: Suplemento 1: V Jornadas Científicas del Instituto de Inmunología Clínica |
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| 12. |
Idioma |
Español=es |
en |
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| 13. |
Relación |
Archivos complementarios |
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| 14. |
Cobertura |
Localización geoespacial, periodo cronológico, muestra de investigación (sexo, edad, etc.) |
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| 15. |
Derechos |
Derechos de autor/a y permisos |
Copyright (c)
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