Características de los trastornos no motores en pacientes con enfermedad de parkinson. Una revisión narrativa.
Characteristics of non-motor disorders in patients with parkinson's disease. A narrative review
Resumen
La enfermedad de Parkinson constituye la segunda enfermedad neurodegenerativa más frecuente (América del Sur 394 por 100 000) la cual afecta el control del movimiento, equilibrio y funciones cognitivas, entre otras. Se caracteriza por presentar síntomas motores y no motores, estos últimos han ganado relevancia, debido a que preceden a los síntomas motores e interfieren negativamente en la calidad de vida de los pacientes. El objetivo del estudio es revisar en la literatura los datos más actualizados, con el tipo y frecuencia de los trastornos no motores diagnosticados en pacientes con enfermedad de Parkinson. Se realizó una búsqueda bibliográfica de los últimos 5 años, en los motores de búsqueda de PubMed y la Biblioteca Virtual de Salud de la OPS, en cada una de ellas se utilizaron ecuaciones de búsqueda a través de términos MeSh/DeCS: Trastornos no motores, Síntomas no motores, Manifestaciones clínicas no motoras y enfermedad de Parkinson. De acuerdo a los resultados obtenidos, se evidenció que los síntomas no motores más frecuentes son los trastornos del ánimo y del sueño, existiendo diferencias entre hombres y mujeres. En conclusión, los síntomas no motores deben ser identificados de manera temprana o de forma retrospectiva, con la finalidad de realizar un manejo terapéutico integral del paciente.
ABSTRACT:
Parkinson's disease is the second most frequent neurodegenerative disease that affects movement control, balance and cognitive functions, among others. It is characterized by presenting motor and non-motor symptoms, the latter have gained relevance because they precede motor symptoms and negatively interfere with the quality of life of patients. The objective of the study is to review the most up-to-date data in the literature, with the type and frequency of non-motor disorders diagnosed in patients with Parkinson's disease. A bibliographic search of the last 5 years was carried out, in the PubMed and PAHO Virtual Health Library search engines, in each of them search equations were used through MeSh/DeCS terms: Non-motor disorders, Non-motor symptoms, Non-motor clinical manifestations and Parkinson's disease. According to the results obtained, it was evidenced that the most frequent non-motor symptoms are mood and sleep disorders, with differences between men and women. In conclusion, non-motor symptoms must be identified early or retrospectively, in order to carry out a comprehensive therapeutic management of the patient.
DOI:
https://doi.org/10.53766/GICOS/2023.08.03.09
Recibido: 15-01-2023. Aprobado: 21-02-2023. Publicado: 26-10-2023
Palabras clave
Referencias
Amara, A. W., Chahine, L. M., Caspell-Garcia, C., Long, J. D., Coffey, C., Högl, B., Videnovic, A., Iranzo, A., Mayer, G., Foldvary-Schaefer, N., Postuma, R., Oertel, W., Lasch, S., Marek, K. & Simuni, T. (2017). Longitudinal assessment of excessive daytime sleepiness in early Parkinson’s disease. Journal of neurology, neurosurgery, and psychiatry, 88(8), 653. https://doi.org/10.1136/JNNP-2016-315023
Ayele, B. A., Zewde, Y. Z., Tafesse, A., Sultan, A., Friedman, J. H. & Bower, J. H. (2021). non-motor symptoms and associated factors in Parkinson’s disease patients in Addis Ababa, Ethiopia: A multicenter cross-sectional study. Ethiopian Journal of Health Sciences, 31(4), 837. https://doi.org/10.4314/EJHS.V31I4.19
Carapellotti, A. M., Stevenson, R. & Doumas, M. (2020). The efficacy of dance for improving motor impairments, non-motor symptoms, and quality of life in Parkinson’s disease: A systematic review and meta-analysis. PLOS ONE, 15(8), e0236820. https://doi.org/10.1371/JOURNAL.PONE.0236820
Chen, J.-H., Hong, C.-T., Wu, D., Chi, W.-C., Yen, C.-F., Liao, H.-F., Chan, L. & Liou, T.-H. (2019). Dementia-Related functional disability in moderate to advanced Parkinson’s disease: assessment using the World Health Organization disability assessment schedule 2.0. International Journal of Environmental Research and Public Health, 16(12), 2230. https://doi.org/10.3390/ijerph16122230
Chen, Y. C., Chen, R. S., Weng, Y. H., Huang, Y. Z., Chen, C. C., Hung, J. & Lin, Y. Y. (2021). The severity progression of non-motor symptoms in Parkinson’s disease: a 6-year longitudinal study in Taiwanese patients. Scientific Reports, 11(1), 14781. https://doi.org/10.1038/S41598-021-94255-9
Eversfield, C. L. & Orton, L. D. (2019). Auditory and visual hallucination prevalence in Parkinson’s disease and dementia with Lewy bodies: a systematic review and meta-analysis. Psychological Medicine, 49(14), 2342. https://doi.org/10.1017/S0033291718003161
Gonçalves, B. M., Barezani, A. L. S., Feital, A. M. B. de F., Souza, M. S. de, Christo, P. P. & Scalzo, P. L. (2020). Low back pain prevalence in Parkinson’s disease. BrJP, 3(3), 310-313. https://doi.org/10.5935/2595-0118.20200192
Instituto Nacional de Estadística y Censos. (2020). Serie 1.1.6 Número de muertes (t) según agrupamiento de causas (Lista de las principales causas de muerte Becker). https://bit.ly/39bS3VY
Jesús, S., Labrador-Espinosa, M. A., Adarmes, A. D., Méndel-Del Barrio, C., Martínez-Castrillo, J. C., Alonso-Cánovas, A., Sánchez Alonso, P., Novo-Ponte, S., Alonso-Losada, M. G., López Ariztegui, N., Segundo Rodríguez, J. C., Morales, M. I., Gastón, I., Lacruz Bescos, F., Clavero Ibarra, P., Kulisevsky, J., Pagonabarraga, J., Pascual-Sedano, B., Martínez-Martín, P., … Villar, M. D. (2020). Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort. Scientific Reports, 10(1), 16893. https://doi.org/10.1038/S41598-020-73756-Z
Liu, R., Umbach, D. M., Tröster, A. I., Huang, X. & Chen, H. (2020). Non-motor symptoms and striatal dopamine transporter binding in early Parkinson’s disease. Parkinsonism y related disorders, 72, 23. https://doi.org/10.1016/J.PARKRELDIS.2020.02.001
Maeda, T., Shimo, Y., Chiu, S. W., Yamaguchi, T., Kashihara, K., Tsuboi, Y., Nomoto, M., Hattori, N., Watanabe, H. & Saiki, H. (2017). Clinical manifestations of nonmotor symptoms in 1021 Japanese Parkinson’s disease patients from 35 medical centers. Parkinsonism and Related Disorders, 38, 54-60. https://doi.org/10.1016/J.PARKRELDIS.2017.02.024/ATTACHMENT/B6F8A2DD-78A3-4A0E-9F0C-0446FBFE6D04/MMC1.DOCX
Magrinelli, F., Picelli, A., Tocco, P., Federico, A., Roncari, L., Smania, N., Zanette, G. & Tamburin, S. (2016). Pathophysiology of motor dysfunction in Parkinson’s disease as the rationale for drug treatment and rehabilitation. Parkinson’s Disease, 2016. https://doi.org/10.1155/2016/9832839
Martínez, R., Gasca, C., Sánchez, Á. y Obeso, J. (2016). Actualización em la enfermedad de Parkinson. Revista Médica Clínica Las Condes, 27(3), 363-379. https://doi.org/10.1016/J.RMCLC.2016.06.010
Melka, D., Tafesse, A., Bower, J. H. & Assefa, D. (2019). Prevalence of sleep disorders in Parkinson’s disease patients in two neurology referral hospitals in Ethiopia. BMC Neurology, 19(1). https://doi.org/10.1186/S12883-019-1431-2
Montalvo, J. P., Montalvo, P. S., Albear, L. E., Intriago, E. R. y Moreira, D. V. (2017). Prevalencia-Enfermedad-de-Parkinson. Revista Ecuatoriana de Neurología, 26 (1), 23-26. https://bit.ly/3PNBvEm
Mukhtar, S., Imran, R., Zaheer, M. & Tariq, H. (2018). Frequency of non-motor symptoms in Parkinson’s disease presenting to tertiary care centre in Pakistan: an observational, cross-sectional study. BMJ Open, 8(5), 19172. https://doi.org/10.1136/BMJOPEN-2017-019172
Oosterveld, L. P., Allen, J. C., Reinoso, G., Seah, S. H., Tay, K. Y., Au, W. L. & Tan, L. C. S. (2015). Prognostic factors for early mortality in Parkinson’s disease. Parkinsonism y Related Disorders, 21(3), 226-230. https://doi.org/10.1016/J.PARKRELDIS.2014.12.011
Ravan, A., Ahmad, F. M. H., Chabria, S., Gadhari, M., y Sankhla, C. S. (2015). Non-motor symptoms in an Indian cohort of Parkinson’s disease patients and correlation of progression of non-motor symptoms with motor worsening. Neurology India, 63(2), 166. https://doi.org/10.4103/0028-3886.156276
Simuni, T., Caspell-Garcia, C., Coffey, C. S., Weintraub, D., Mollenhauer, B., Lasch, S., Tanner, C. M., Jennings, D., Kieburtz, K., Chahine, L. M. & Marek, K. (2018). Research paper: Baseline prevalence and longitudinal evolution of non-motor symptoms in early Parkinson’s disease: the PPMI cohort. Journal of Neurology, Neurosurgery, and Psychiatry, 89(1), 78. https://doi.org/10.1136/JNNP-2017-316213
van Wamelen, D. J., Sauerbier, A., Leta, V., Rodriguez-Blazquez, C., Falup-Pecurariu, C., Rodriguez‐Violante, M., Rizos, A., Tsuboi, Y., Metta, V., Bhidayasiri, R., Bhattacharya, K., Borgohain, R., Prashanth, L. K., Rosales, R., Lewis, S., Fung, V., Behari, M., Goyal, V., Kishore, A., … Chaudhuri, K. R. (2021). Cross-sectional analysis of the Parkinson’s disease Non-motor International Longitudinal Study baseline non-motor characteristics, geographical distribution and impact on quality of life. Scientific Reports, 11(1), 9611. https://doi.org/10.1038/S41598-021-88651-4
Enlaces refback
- No hay ningún enlace refback.
Depósito Legal Electrónico: ME2016000090
ISSN Electrónico: 2610-797X
DOI: https://doi.org/10.53766/GICOS
       |
| Se encuentra actualmente registrada y aceptada en las siguientes base de datos, directorios e índices: | |||
|  |  |  |
 |  |  |  |
 |  |  |  |
 |  |  |  |
 |  |  |  |
 |  |  |  |
 |  | ||
Todos los documentos publicados en esta revista se distribuyen bajo una
Licencia Creative Commons Atribución -No Comercial- Compartir Igual 4.0 Internacional.
Por lo que el envío, procesamiento y publicación de artículos en la revista es totalmente gratuito.