Evaluación del efecto de un tratamiento combinado utilizando fórmulas lipolíticas y de estimulación celular para el remodelado mandibular
Resumen
DOI: https://doi.org/10.53766/AcBio/2023.14.27.04
El modelado mandibular es una causa frecuente de consulta en medicina estética debido al impacto en la autoestima de las pacientes que al envejecer pierden la línea mandibular. Por eso el objetivo de este trabajo fue estudiar el efecto del tratamiento combinado utilizando fórmulas lipolíticas y de estimulación celular para la disminución de la grasa submentoniana, bolas de Bichat y remodelado mandibular. Se evaluaron 159 mujeres (47,1 ± 11,7 años). La fórmula lipolítica (aplicación subcutánea) contiene L-carnitina, fosfatidilcolina e hidrolizado de algas rojas, cafeína, silicio orgánico y troxerutina. La fórmula intradérmica para reafirmar la línea mandibular contiene hidrolizado de algas rojas, silicio orgánico, myricelineTM, péptidos biomiméticos y DMAE. Se aplicaron inyecciones de la fórmula intradérmica en la línea mandibular y pliegue cutáneo del surco nasomentoniano, en conjunto con una formula lipolítica en la zona submentoniana y bolas de Bichat. 45% de las pacientes presentaron niveles de grasa submentoniana leve, 25% moderada y 30% grave. Todas las pacientes lograron una reducción significativa de la papada, mayor definición de la línea mandibular y disminución de las arrugas y de los pliegues de la piel producto del tejido adiposo localizado, mejorando significativamente la tersura de la piel. Análisis de imágenes mostraron una disminución (p<0,05) del 2% en el ángulo mentocervical y un 10% en el área tratada. Este estudio proporciona evidencias semicuantitativas de que la combinación de una fórmula intradérmica reafirmante con una lipolítica subcutánea es un método mínimamente invasivo, seguro y eficaz para la reducción de la grasa submentoniana, y el remodelado de la definición de la línea mandibular con efectos apreciables de rejuvenecimiento de la piel.
Recibido: 14/07/2023
Aceptado: 28/09/2023
Publicado en línea: 09/11/2023
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Jagdeo J, Keaney T, Narurkar V, Kolodziejczyk J, Gallagher CJ. Facial treatment preferences among aesthetically oriented men. Dermatologic Surg 2016;42(10):1155–63.
Narurkar V, Shamban A, Sissins P, Stonehouse A, Gallagher C. Facial treatment preferences in aesthetically aware women. Dermatologic Surg 2015;41:S153–60.
Ellenbogen R, Karlin J V. Visual criteria for success in restoring the youthful neck. Plast Reconstr Surg 1980;66(6):826–37.
Forte AJ, Andrew TW, Colasante C, Persing JA. Perception of Age, Attractiveness, and Tiredness After Isolated and Combined Facial Subunit Aging. Aesthetic Plast Surg 2015;39(6):856–69.
Rohrich RJ, Pessa JE. The fat compartments of the face: Anatomy and clinical implications for cosmetic surgery. Plast Reconstr Surg 2007;119(7):2219–27.
Shridharani SM. Novel Surface Anatomic Landmarks of the Jowl to Guide Treatment with ATX-101. Plast Reconstr Surg - Glob Open 2019;7(10):e2459.
Reece EM, Pessa JE, Rohrich RJ. The mandibular septum: Anatomical observations of the jowls in aging - Implications for facial rejuvenation. Plast Reconstr Surg 2008;121(4):1414–20.
Reece EM, Rohrich RJ. The Aesthetic Jaw Line: Management of the Aging Jowl. Aesthetic Surg J 2008;28(6):668–74.
Patel BCK. Aesthetic surgery of the aging neck: Options and techniques. Orbit 2006;25(4):327–56.
Toplu G, Altinel D. Facial contouring and rejuvenation with the use of fat injection. Düzce Üniversitesi Saglik Bilim Enstitüsü Derg 2021;11(1):61–6.
Schlessinger J, Weiss SR, Jewell M, Narurkar V, Weinkle S, Gold MH, Bazerkanian E. Perceptions and practices in submental fat treatment: A survey of physicians and patients. Skinmed 2013;11(1):27–31.
Sullivan PK, Hoy EA, Mehan V, Singer DP. An anatomical evaluation and surgical approach to the perioral mound in facial rejuvenation. Plast Reconstr Surg 2010;126(4):1333–40.
Fogli A. Rajeunissement jugal et traitement des bajoues. Ann Chir Plast Esthétique 2017;62(5):424–34.
Zahra T, Abd Halim M, Zayed A, Zeid T, Zeina A. Comparative Study of High-Intensity Focused Ultrasound (HIFU) Versus Laser Assisted Liposuction in Neck Tightening and Correction of Double Chin Deformity among Young Females. Egypt J Plast Reconstr Surg 2020;44(1):111–8.
Azuelos A, Sidahmed-Mezi M, La Padula S, Aboud C, Meningaud JP, Hersant B. High-Intensity Focused Ultrasound: A Satisfactory Noninvasive Procedure for Neck Rejuvenation. Aesthetic Surg J 2019;39(8):NP343–51.
Locketz GD, Bloom JD. Percutaneous Radiofrequency Technologies for the Lower Face and Neck. Facial Plast Surg Clin North Am 2019;27(3):305–20.
Polacco MA, Luu T, Ni G, Attenello NH, Dicarlo A, Maas CS. A Single-Center, Prospective Trial Investigating Effects of Combined Infrared, Radiofrequency, Mechanical Massage, and Suction Treatment on Submental and Lateral Neck Tissue Contouring. Am J Cosmet Surg 2021;38(1):42–9.
Park SH, Kim DW, Lee MA, Yoo SC, Rhee SC, Koo SH, Seol GH, Cho EY. Effectiveness of mesotherapy on body contouring. Plast Reconstr Surg 2008;121(4).
Duncan D, Rotunda AM. Injectable Therapies for Localized Fat Loss: State of the Art. Clin Plast Surg 2011;38(3):489–501.
Kraemer WJ, Volek JS, Dunn-Lewis C. L-carnitine supplementation: Influence upon physiological function. Curr Sports Med Rep 2008;7(4):218–23.
Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: Historical clarification and review. Dermatologic Surg 2006;32(4):465–80.
Fonseca Capdevila E, Hurtado Bouza JL. Adipocitólisis con fosfatidilcolina. Piel 2009;24(3):117–8. 23. Hübner NF, Horch RE, Polykandriotis E, Rau TT, Dragu A. A Histopathologic and Immunohistochemical Study on Liquification of Human Adipose Tissue Ex Vivo. Aesthetic Plast Surg 2014;38(5):976–84.
Sañudo A, Vallejo F, Sierra M, Hoyos JG, Yepes S, Wolff JC, Correa LA, Montealegre C, Navarro P, Bedoya E, Sanclemente G. Nontuberculous mycobacteria infection after mesotherapy: Preliminary report of 15 cases. Int J Dermatol 2007;46(6):649–53.
Al-Khenaizan S. Facial cutaneous ulcers following mesotherapy. Dermatologic Surg 2008;34(6):832–5.
Davis MDP, Wright TI, Shehan JM. A complication of mesotherapy: Noninfectious granulomatous panniculitis. Arch Dermatol 2008;144(6):808–9.
Duncan DI. Response to “Injection Lipolysis With Phosphatidylcholine and Deoxycholate.” Aesthetic Surg J 2013;33(7):1073–5.
Shridharani SM. Improvement in jowl fat following ATX-101 treatment: Results from a single-site study. Plast Reconstr Surg 2020;145(4):929–35.
Montes JR, Santos E, Chillar A. Jowl Reduction With Deoxycholic Acid. Dermatologic Surg 2020;46(1):78–85.
Kandhari R, Kaur I, Sharma D. Mesococktails and mesoproducts in aesthetic dermatology. Vol. 33, Dermatologic Therapy. Blackwell Publishing Inc.; 2020. p. e14218.
Escalante G, Bryan P, Rodriguez J. Effects of a topical lotion containing aminophylline, caffeine, yohimbe, l-carnitine, and gotu kola on thigh circumference, skinfold thickness, and fat mass in sedentary females. J Cosmet Dermatol 2019;18(4):1037–43.
Thomas M, D’Silva J, Borole A. Injection lipolysis: A systematic review of literature and our experience with a combination of phosphatidylcholine and deoxycholate over a period of 14 years in 1269 patients of Indian and South East Asian origin. J Cutan Aesthet Surg 2018;11(4):222–8.
Amin SP, Phelps RG, Goldberg DJ. Mesotherapy for facial skin rejuvenation: A clinical, histologic, and electron microscopic evaluation. Dermatologic Surg 2006;32(12):1467–72.
Vineetha Reddy N, Jyothi M, Venkatesh P, Hepcy Kalarini D, Prema R. Mesotherapy in face. ijresm 2019;2(10):822–9.
Yang TH, Chiu CY, Lu TJ, Liu SH, Chiang MT. The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (Gelidium amansii) Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters. Mar Drugs 2019;17(9).
Jung GS. Effectiveness of Local Fat-Dissolving Solution Injection. Aesthetic Surg J 2019;39(5):NP156–8.
Klein SM, Schreml S, Nerlich M, Prantl L. In vitro studies investigating the effect of subcutaneous phosphatidylcholine injections in the 3T3-L1 adipocyte model: Lipolysis or lipid dissolution? Plast Reconstr Surg 2009;124(2):419–27.
Wutzke KD, Lorenz H. The effect of L-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects. Metabolism 2004;53(8):1002–6.
Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. J Cosmet Dermatol 2005;4(4):308–13.
Malakar B, Mohanty K. The Budding Potential of Algae in Cosmetics. In: Algae. Springer Singapore; 2021. p. 181–99.
Kim JY, Kwon MS, Son J, Kang SW, Song Y. Selective effect of phosphatidylcholine on the lysis of Adipocytes. PLoS One 2017;12(5):e0176722.
Herman A, Herman AP. Caffeine’s mechanisms of action and its cosmetic use. Skin Pharmacol Physiol 2012;26(1):8–14.
Xiao Y, Li M, Mao P, Yang L, Qu L. Enzymatic synthesis, antioxidant ability and oil-water distribution coefficient of troxerutin fatty acid esters. Grain Oil Sci Technol 2019;2(3):78–84.
Malinska H, Hüttl M, Oliyarnyk O, Markova I, Poruba M, Racova Z, Kazdova L, Vecera R. Beneficial effects of troxerutin on metabolic disorders in non-obese model of metabolic syndrome. PLoS One 2019;14(8).
Chen L, Lin X, Teng H. Emulsions loaded with dihydromyricetin enhance its transport through Caco-2 monolayer and improve anti-diabetic effect in insulin resistant HepG2 cell. J Funct Foods 2020;64:103672.
Zhang J, Chen Y, Luo H, Sun L, Xu M, Yu J, Zhou Q, Meng G, Yang S. Recent update on the pharmacological effects and mechanisms of dihydromyricetin. Front Pharmacol 2018;9(OCT).
Gazitaeva ZI, Drobintseva AO, Chung Y, Polyakova VO, Kvetnoy IM. Cosmeceutical product consisting of biomimetic peptides: Antiaging effects in vivo and in vitro. Clin Cosmet Investig Dermatol 2017;10:11–6.
Grossman R. The role of dimethylaminoethanol in cosmetic dermatology. Vol. 6, American Journal of Clinical Dermatology. Am J Clin Dermatol; 2005. p. 39–47.
Manzini JL. Declaración de Helsinki: Principios éticos para la investigación médica sobre sujetos humanos. Acta Bioeth 2000;6(2):321–34.
WHO. Operational Guidelines for Ethics Committees That Review Biomedical Research [Internet]. 2012. Available from: https://www.who.int/tdr/publications/documents/ethics.pdf
Rotunda AM. Injectable treatments for fat. In: Update in Cosmetic Dermatology. Springer Berlin Heidelberg; 2013. p. 181–202.
Rotunda AM. Injectable treatments for adipose tissue: Terminology, mechanism, and tissue interaction. Lasers Surg Med 2009;41(10):714–20.
Duncan D, Palmer M. Fat reduction using phosphatidylcholine/sodium deoxycholate injections: Standard of practice. Aesthetic Plast Surg 2008;32(6):858–72.
Sivagnanam G. Mesotherapy-The french connection. J Pharmacol Pharmacother. 2010;1(1):4–8.
Lacarrubba F, Tedeschi A, Nardone B, Micali G. Mesotherapy for skin rejuvenation: Assessment of the subepidermal low-echogenic band by ultrasound evaluation with cross-sectional B-mode scanning. Dermatol Ther 2008;21(SUPPL. 3).
Adeva-Andany MM, Calvo-Castro I, Fernández-Fernández C, Donapetry-García C, Pedre-Piñeiro AM. Significance of l-carnitine for human health. IUBMB Life 2017;69(8):578–94.
Wang HMD, Chen CC, Huynh P, Chang JS. Exploring the potential of using algae in cosmetics. Bioresour Technol 2015;184:355–62.
Liu L, Zhou M, Lang H, Zhou Y, Mi M. Dihydromyricetin enhances glucose uptake by inhibition of MEK/ERK pathway and consequent down-regulation of phosphorylation of PPAR? in 3T3-L1 cells. J Cell Mol Med 2018;22(2):1247–56.
Rauso R, Salti G. A CE-marked drug used for localized adiposity reduction: A 4-year experience. Aesthetic Surg J 2015;35(7):850–7.
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