Envíe este artículo por correo electrónico 
(Una revisión comparativa sobre la resolución de la bioimpresión 3D sobre cultivos celulares 2D en modelos de cáncer)
Resumen
El microambiente tumoral, compuesto por células no neoplásicas y la matriz extracelular, desempeña un papel fundamental en la progresión del cáncer. Los cultivos celulares bidimensionales (2D) tradicionales no logran captar su complejidad, lo que resulta en disparidades en la respuesta a los fármacos en comparación con los modelos tridimensionales (3D). Investigaciones recientes destacan la precisión de los modelos de cáncer bioimpresos en 3D, revolucionando la investigación oncológica. La bioimpresión 3D ofrece diversas aplicaciones, incluyendo modelos tumorales personalizados para el análisis individualizado de fármacos. Estos modelos replican las condiciones fisiológicas, proporcionando un cribado preciso de fármacos para su
eficacia y toxicidad. También facilita el estudio de los mecanismos de metástasis y la identificación de dianas terapéuticas. Además, la bioimpresión 3D ayuda a optimizar los tratamientos contra el cáncer, como las terapias génicas y las inmunoterapias, y permite la administración precisa de fármacos a las células cancerosas. Apoya la formación médica con herramientas de formación realistas y ofrece una alternativa ética a la experimentación con animales, reduciendo potencialmente su necesidad en la investigación oncológica. En esencia, la bioimpresión 3D está impulsando la investigación oncológica al proporcionar modelos de alta precisión que imitan fielmente el microambiente tumoral, mejorando la medicina personalizada, el cribado de fármacos, el desarrollo terapéutico y la educación. La presente revisión profundiza en las aplicaciones multifacéticas de la bioimpresión 3D en la investigación del cáncer, al tiempo que explora futuras direcciones e innovaciones en la bioimpresión 3D para modelos de cáncer.
Received: November 11th, 2024.
Acepted: March 20th, 2025.
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