Correlación entre niveles de ferritina sérica y unidades de transfusión recibidas por pacientes con anemias hereditarias hemolíticas en el estado de Zulia, Venezuela
Resumen
Correlations between ferritin levels and transfusion units received by pacients with hereditary hemolytic anemia in the state of Zulia, Venezuela
Abstract
Blood transfusions are a commonly used treatment or patients with hereditary hemolytic anemias, such as: sickle cell anemia (SCA) and / or beta thalassemia (βT). Ferritin levels are constantly monitored in these patients for early detection of iron overload. The aim study was to determine whether or not there was a correlation between serum ferritin values and the number of units of packed erythrocyte transfused in patients with SCA and βT major or intermedia for a year. A prospective study was performed with 39 patients,2 were diagnosed with SCA and 17 were diagnosed with βT. Their ages ranked between 4 to 82 years of age. These patients were treated at the “Instituto Hematológico de Occidente-Banco de Sangre Estado Zulia and Hospital Universitario de Maracaibo – Venezuela”. Serum ferritin was determined by a chemiluminescence method. The mean and standard deviation for ferritin values were 915.4 ± 567.8 ng / ml for patients with SCA and 3,338 ± 874.6 for βT (p: 0.0001). The units of packed-red blood cells transfused were 6 ± 2.3 and 21 ± 7.5, respectively (p = 0.0001). There was a statistically significant correlation between the number of packed-red blood cell units transfused and the ferritin values in the SCA group (r = 0.832, p = 0.0001), and the βT group (r = 0.491, p = 0.045). The results of this study suggest a strong correlation between serum ferritin concentrations and erythrocyte concentrate units transfused in patients with SCA but not in patients with βT.
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Depósito Legal: ppi201102ME3935 - ISSN: 2477-9369.
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