Efectividad del uso de probióticos como tratamiento adyuvante para el manejo de rinitis alérgica. Instituto Autónomo Hospital Universitario de Los Andes, 2024
Effectiveness of the use of probiotics as an adjuvant treatment For the management of allergic rhinitis. Autonomous Institute University Hospital of Los Andes, 2024

Jessica Milano, Miroswa Espinoza, Erika Uzcátegui, Herson Arias

Resumen


RESUMEN
El estudio tuvo como objetivo evaluar el efecto de probiótico como tratamiento coadyuvante de rinitis alérgica en el servicio de Otorrinolaringología, Instituto Autónomo Hospital Universitario de Los Andes, 2024. Investigación de tipo comparativa, diseño experimental con dos grupos, a uno se le aplicó tratamiento convencional y al otro el tratamiento convencional más el probiótico, para determinar el efecto en los resultados de laboratorio y la calidad de vida antes y después de cada tratamiento. Se utilizó el cuestionario SNOT-22 para la calidad de vida de los pacientes. La muestra estuvo conformada por 50 pacientes distribuidos de manera aleatoria y equitativa entre los dos grupos de estudio. Resultados: 64% femenino, edad 25,94 ± 15,482 años. Se determinó una diferencia estadísticamente significativa (p<0,001) en los promedios de la IgE, Eosinofilia HC, Eosinofilia MN, FND, FNI y calidad de vida antes y después de cada tratamiento. Conclusión: se determinaron efectos positivos entre el antes y el después de cada tratamiento, sin diferencias estadísticas entre ambos tratamientos con una pequeña diferencia a favor del grupo con probióticos.

ABSTRACT
The study aimed to evaluate the effect of probiotics as an adjunctive treatment for allergic rhinitis in the Otolaryngology Department, Autonomous University Hospital of Los Andes, 2024. This was a comparative study with an experimental design involving two groups, one receiving conventional treatment and the other receiving conventional treatment plus probiotics, to determine the effect on laboratory results and quality of life before and after each treatment. The SNOT-22 questionnaire was used to assess patients' quality of life. The sample consisted of 50 patients randomly and equally distributed between the two study groups. Results: 64% female, age 25.94 ± 15.482 years. A statistically significant difference (p<0.001) was determined in the averages of IgE, HC eosinophilia, MN eosinophilia, FND, FNI, and quality of life before and after each treatment. Conclusion: Positive effects were determined between before and after each treatment, with no statistical differences between the two treatments and a small difference in favor of the probiotic group.

Recibido: 25-07-2025
Aceptado: 01-12-2025
Publicado: 02-02-2026


Palabras clave


rinitis alérgica; probióticos; tratamiento convencional; otorrinolaringología. allergic rhinitis; probiotics; conventional treatment; otolaryngology.

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Referencias


Anand, S., & Mande, S. S. (2018). Diet, microbiota and gut-lung connection. Frontiers in Microbiology, 9, 2147. https://doi.org/10.3389/fmicb.2018.02147

Chao, L., Shunlin, P., Mao, L., Xudong, A., & Zhiqing, L. (2022). The efficacy and safety of probiotics for allergic rhinitis: A systematic review and meta-analysis. Frontiers in Immunology, 13, 848279. https://doi.org/10.3389/fimmu.2022.848279

Ciprandi, G., & Tosca, M. A. (2022). Probiotics in allergic rhinitis management: Is there a positioning for them? Allergies, 2(3), 119–127. https://doi.org/10.3390/allergies2030011

Colas, C., Galera, H., Añibarro, B., Soler, R., Navarro, A., Jauregui, I., Davila, I., Ferrer, M., & Valero, A. (2012). Disease severity impairs sleep quality in allergic rhinitis (The SOMNIAAR study). Clinical and Experimental Allergy, 42(7), 1080–1087.

Corporación de Salud del Estado Mérida, Unidad de Estadística. (s.f.). Epidemiología regional. Instituto Nacional de Estadística. http://www.ine.gob.ve/documentos/SEN/ioe2013_/documentos/4152114_Morbilidad_2010.pdf

Dennis-Wall, J. C., Culpepper, T., Nieves, C., Jr., Rowe, C. C., Burns, A. M., Rusch, C. T., Federico, A., Ukhanova, M., Waugh, S., Mai, V., Christman, M. C., & Langkamp-Henken, B. (2017). Probiotics (Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2) improve rhinoconjunctivitis-specific quality of life in individuals with seasonal allergies: A double-blind, placebo-controlled, randomized trial. The American Journal of Clinical Nutrition, 105(3), 758–767. https://doi.org/10.3945/ajcn.116.140012

Georgalas, C. (2011). The role of the nose in snoring and obstructive sleep apnoea: An update. European Archives of Oto-Rhino-Laryngology, 268(9), 1365–1373.

Guadarrama-Ortíz, P., Flores-Vázquez, J. C., Carnalla-Cortés, M., & Choreño-Parra, J. A. (2018). Probióticos ¿coadyuvantes en el tratamiento médico? Medicina Interna de México, 34(4), 574-581. https://doi.org/10.24245/mim.v34i4.1878

Ivory, K., Chambers, S. J., Pin, C., Prieto, E., Arqués, J. L., & Nicoletti, C. (2008). Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis. Clinical and Experimental Allergy, 38(8), 1282–1289. https://doi.org/10.1111/j.1365-2222.2008.03025.x

Koinis-Mitchell, D., Craig, T., Esteban, C. A., & Klein, R. B. (2012). Sleep and allergic disease: A summary of the literature and future directions for research. Journal of Allergy and Clinical Immunology, 130(6), 1275–1281.

Luo, C., Peng, S., Li, M., Ao, X., & Liu, Z. (2022). The efficacy and safety of probiotics for allergic rhinitis: A systematic review and meta-analysis. Frontiers in Immunology, 13, 848279. https://doi.org/10.3389/fimmu.2022.848279

Meltzer, E. O. (2016). Allergic rhinitis: Burden of illness, quality of life, comorbidities, and control. Immunology and Allergy Clinics of North America, 36(2), 235–248.

Meltzer, E. O., Blaiss, M. S., Naclerio, R. M., Stoloff, S. W., Derebery, M. J., Nelson, H. S., Boyle, J. M., & Wingertzahn, M. A. (2012). Burden of allergic rhinitis: Allergies in America, Latin America, and Asia-Pacific adult surveys. Allergy and Asthma Proceedings, 33(Suppl 1), S113–S141.

Muliol, J., Maurer, M., & Bousquet, J. (2008). Sleep and allergic rhinitis. Journal of Investigational Allergology and Clinical Immunology, 18(6), 415–419.

Nathan, R. A. (2007). The burden of allergic rhinitis. Allergy and Asthma Proceedings, 28(1), 3–9.

Ried, K., Travica, N., Paye, Y., & Sali, A. (2022). Effects of a probiotic formulation on seasonal allergic rhinitis in adults—A randomized double-blind placebo-controlled trial: The Probiotics for Hay Fever Trial. Frontiers in Nutrition, 9, 887978. https://www.frontiersin.org/articles/10.3389/fnut.2022.887978

Sadeghi-Shabestari, M., Jabbari Moghaddam, Y., Rezapoor, H., & Sohrabpour, M. (2020). Effect of probiotics on allergic rhinitis: A randomized, controlled, clinical trial. Galen Medical Journal, 9, e1918. https://doi.org/10.31661/gmj.v9i0.1918

Singhal, A., Agrawal, P., Chatterji, P., Matreja, P. S., & Mahmood, T. (2024). Comparison of the efficacy and safety of bilastine 20 mg versus fexofenadine 180 mg for treatment of perennial allergic rhinitis: Randomized controlled study. Indian Journal of Otolaryngology and Head & Neck Surgery, 76(5), 4025–4030. https://doi.org/10.1007/s12070-024-04770-0

U, P. S., G, B. A., & Chadha, B. (2023). Comparative case study of efficacy of oral bilastine monotherapy to concomitant administration of oral bilastine with probiotic in patients with allergic rhinitis. Indian Journal of Otolaryngology and Head & Neck Surgery, 75(3), 2137–2141. https://doi.org/10.1007/s12070-023-03818-x

Universidad Central de Venezuela. (2014, diciembre 18). Rinitis y asma, una dupla casi inseparable. http://www.ucv.ve/organizacion/rectorado/direcciones/direccion-de-informacion-y-comunic-dic/detalle-noticias-dic/article/rinitis-y-asma-una-dupla-casi-inseparable.html

World Allergy Organization. (2013). WAO white book on allergy: Update 2020. https://www.worldallergy.org/education-and-programs/education/allergic-disease-resource-center/professionals/in-depth-review-of-allergic-rhinitis

Ye, S. F., Liu, Z., Wang, Y. F., He, P., Wen, L. J., & Teng, B. (2017). The therapeutic effect of probiotics on allergic rhinitis: A Meta analysis [Article in Chinese]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery, 31(6), 467–474.

Wang, X., Tan, X., & Zhou, J. (2022). Effectiveness and safety of probiotic therapy for pediatric allergic rhinitis management: A systematic review and meta-analysis. International Journal of Pediatric Otorhinolaryngology, 162, 111300. https://doi.org/10.1016/j.ijporl.2022.111300

Zajac, A. E., Adams, A. S., & Turner, J. H. (2015). A systematic review and meta-analysis of probiotics for the treatment of allergic rhinitis. International Forum of Allergy & Rhinology, 5(6), 524–532. https://doi.org/10.1002/alr.21492


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